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For instance, it has been shown that CD28 CAR T cells induce more severe adverse effects than 4-1BB CAR T cells, including higher frequency of grade III-IV CRS, grade I-II neurotoxicity and episodes of severe ICANS [22]

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Introduction SARS-CoV-2 infection can result in asymptomatic or symptomatic presentations, ranging from mild to fatal coronavirus disease 2019 (COVID-19) ( However, a substantial number of patients recovering from COVID-19 have reported a wide range of symptoms that last for many months or years after the onset of acute infection ( Any acute infection that damages multiple organs (e.g